I love Philosophy's When Hope Is not Enough serum. I order it through QVC and it's a tad pricey, but well worth it. I use it at night after I cleanse my face. I apply this serum and then my moisturizer. Serums always go on 1st. I rotate my moisturizers, because I don't want my skin getting use to 1 product and after time, it doesn't do the same job as before.