After trying this for 3 days and night (the night cream) I have had an allergic reaction of numbness and tingling in my lips and face, with some redness and hot to touch. Happy to report that the Canadian version of Nerium (Optimera) does not have the cancer cell killing plant extract Oleander due to Canadian regulations. Woohoo to Canadian regulations for getting something right.

On the flip side from all that I have been able to search out most of the ingredients are all natural items, just this girl seems to be more reactive to natural than the synthetic it would seem.