Hoping to harness the magical Smurf-essence, evil wizard Gargamel creates a pair of Smurflike creatures, called Naughties. However, only a real Smurf can give Gargamel what he wants, so he kidnaps Smurfette to force her to cast a spell that will transform the Naughties into Smurfs. Papa, Clumsy and the rest of the Smurfs reunite with their human friends Patrick (Neil Patrick Harris) and Grace (Jayma Mays) to rescue Smurfette from the wizard's clutches.

Smurfette shines in this movie. The family rallies together to come to her rescue. When Smurfs lend a hand they can accomplish anything. Gargamel has concocted an evil plan once again and its up to the Smurfs to save their precious Smurfette. There can only be one Smurfette and time will tell what Gargamel has been up to.